Patrick S. Callery, Ph.D.
Professor of Pharmaceutical Sciences
Department of Basic Pharmaceutical Sciences
West Virginia University
P.O. Box 9530
Morgantown, WV 26506-9530
Phone: (304)293.1482
Fax: (304)293.2576
E-Mail:
pcallery@hsc.wvu.edu
Link to CV
Biosketch:
Dr. Patrick Callery is a professor of pharmaceutical sciences in the Department of Basic Pharmaceutical Sciences in the West Virginia University School of Pharmacy and a member of the Mary Babb Randolph Cancer Center. He earned his B.S degree in Pharmacy from the University of Utah and Ph.D. in pharmaceutical chemistry from the University of California San Francisco. He completed postdoctoral study in medicinal chemistry at the University of Maryland Baltimore where he was appointed as an assistant professor. Dr. Callery came to WVU in 1997 as professor and chair of the department of basic pharmaceutical sciences.
Dr. Callery’s eclectic research activity has contributed to multiauthored scientific publications and drug discovery patents. Recent research accomplishments are in the areas of the forensic toxicology of smoked drugs, reactive metabolites of anticancer drugs, novel drug metabolism reactions, prodrugs of natural products, and new classes of monoamine oxidase and histone demethylase inhibitors with therapeutic potential.
Education:
Post-doctoral Training- University of Maryland
Graduate Training - Ph.D., Pharmaceutical Chemistry, University of California San Francisco
Undergraduate Training - B.S., Pharmacy, University of Utah
Research Interests:
Anticancer drug discovery
Recent/Current Grants
Research Techniques
Mass spectrometry for structure elucidation and drug quantification. Drug discovery techniques emphasizing enzyme inhibition mechanism studies and identification of anticancer drug prototypes.
Selected Publications:
Cooper, A.J.L., Younis, I.R., Niatsetskaya, Z.V., Krasnikov, B.F., Pinto, J.T., Petros, W.P., and Callery, P.S. (2008) Enzymatic conversion of the cysteine S-conjugate of the anticancer drug busulfan to tetrahydrothiophene, pyruvate and ammonium. Drug Metab Dispos 36, 1546-1552.
Peer, C.J., Clay, D.J., Glover, H.L., Renninger, K.L., Kraner, J.C., and Callery, P.S. (2008) Direct injection mass spectrometric confirmation of multiple drugs in overdose cases from postmortem blood using ESI- MS-MS and MS3. J Anal Tox. 32, 709-714.
Shakleya, D.M., Plumley, A.E., Kraner, J.C., Bell, S.C., and Callery, P.S. (2008) Case Study: Trace evidence of trans-phenylpropene as a marker of smoked methamphetamine. J Anal Tox. 32, 705-708.
Younis, I.R., Elliott, M., Peer, C.J., Cooper, A.J.L., Pinto, J.T., Konat, G.W., Kraspulski, M., Petros, W.P., and Callery, P.S. (2008) Dehydroalanine analog of glutathione: An electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1. J Pharmacol Exp Ther, 327, 770-776. PMCID: PMC2678891
Younis, I.R., Stamatakis, M.K., Callery, P.S., Meyer-Stout, P.J. (2009) Influence of pH on the dissolution of folic acid supplements. Int J Pharm. 367, 97-102.
Dabkowski, E.R., Williamson, C.L., Bukowski, V.C., Chapman, R.S., Leonard, S.S., Peer, C.J., Callery, P.S., Hollander, J.M. (2009) Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations. Am J Physiol Heart Circ Physiol. 296, H359-69. PMCID: PMC2643887
Hanson, M.L., Peer, C.J., Brundage, R., Callery, P.S., Brundage, K., Schafer, R., Eremin, S., Barnett, J.B. (2010) Subcellular localization of the amide class herbicide 3,4-dichloropropionanilide (DCPA) in T cells and hepatocytes. J Toxicol Environ Health A. 73, 1-4. PMCID: PMC2888467
Nishikawa, R.K., Bell, S.C., Kraner, J.C., Callery, P.S. (2009) Potential biomarkers of smoked fentanyl utilizing pyrolysis gas chromatography-mass spectrometry. J Anal Toxicol. 33, 418-422.
Cooper, A.J., Krasnikov, B.F., Niatsetskaya, Z.V., Pinto, J.T., Callery, P.S., Villar, M.T., Artigues, A., Bruschi, S.A. (2011) Cysteine S-conjugate beta-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents. Amino Acids. 41, 7-27.
Wichitnithad, W., McManus, T.J., Callery, P.S. (2010) Identification of isobaric product ions in electrospray ionization mass spectra of fentanyl using multistage mass spectrometry and deuterium labeling. Rapid Commun Mass Spectrom. 24, 2547-2553.
Wichitnithad W., Nimmannit U., Callery P.S., Rojsitthisak P. (2011) Effects of different carboxylic ester spacers on chemical stability, release characteristics, and anticancer activity of mono-PEGylated curcumin conjugates. J Pharm Sci., 100, 5206-5218.
Cooper A.J.L., Pinto J.T., Callery P.S. (2011) Reversible and irreversible protein glutathionylation: biological and clinical aspects. Expert Opin Drug Metab Toxicol. 7, 891-910.
Wichitnithad W., O’Callaghan, J.P., Miller, D.B., Train, B.C., Callery, P.S. Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines. Bioorg Med Chem. DOI information: 10.1016/j.bmc.2011.10.038
Patents
M.D. Loberg,
P.S. Callery, and M. Cooper, New Pharmaceutical Chelates and Methods of External Imaging.
U.S. Patent 4,017,596, 1977, plus foreign patents. Marketed in U.S. by New England Nuclear and in Canada by Merck Frosst.
P.S. Callery, J. Wright, N. Zenker, and C.S. Stone, Antihypertensive Benzoxazolones. U.S. Patent 4,034,100, 1977, plus foreign patents. Assigned to Merck and Co.
P.S. Callery, J. Wright, and N. Zenker, Antihypertensive Benzimidazolones. U.S. Patent 4,073,929, 1977,plus foreign patents. Assigned to Merck and Co.
P.S. Callery, M.J. Egorin, Y. Li, and Z.-M. Yuan, Diaziridinylpolyamine Anti-Cancer Agents. U.S. Patent 5,612,329, 1997.
T.S. Tracy, D.D. Glover, P.S. Callery, A.P. Soisson, and J.E. Smith, Cervical Isolation and Delivery Apparatus. U.S.
Patent 7,165,550, 2007. Licensed in 2011
P.S. Callery, W. Wichitnithad and G. Konat, N-Substituted analogs of tetrahydropyridine containing a polyamine group. Provisional patent applied for July 2010.
P.S. Callery and W. Wichitnithad, Tetrahydropyridines as novel inhibitors of monoamine oxidase. Provisional patent applied for November 2010.
Positions:
Assistant Professor, University of Maryland Baltimore, 1974-1978
Associate Professor, University of Maryland Baltimore, 1978-1990
Professor, University of Maryland Baltimore, 1990-1997
Adjunct Professor of Chemistry, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1993-
Professor and Chair, Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 1997-2009
Member, Mary Babb Randolph Cancer Center, 1997 -
Professor of Pharmaceutical Sciences, 2009 -
Teaching
PharmD: pharmacokinetics and physical pharmacy
PhD: graduate student seminar course and drug discovery & development
Special Service
Class of 2014 class advisor
Professional Memberships
American Chemical Society
Society of Forensic Toxicologists